A loss of global cognitive ability that interferes with normal social or occupational function.

The process of distinguishing a disease from other conditions with similar clinical features. In PSP, it involves differentiating it from disorders such as Parkinson’s disease or other PSP-mimicking syndromes.

Is a generic measure of health outcome that can be used in cost utility analysis. DALYs are a measure of overall disease burden, expressed as the number of years lost due to ill health, disability or mortality. 

The overall impact of a disease on patients, caregivers, and healthcare systems – including physical, emotional, social, and economic effects.

A treatment aimed at addressing the underlying cause and altering its natural progression. These work by targeting the root mechanisms that drive the disease, potentially slowing down, halting or even reversing its course.

A study design where neither participants nor researchers know which treatment each participant receives, reducing the likelihood of bias in the results.

A speech disorder of neurological origin marked by impaired articulation.

An alteration or distortion in the normal sense of taste.

Difficulty swallowing that often requires changes in diet. Some individuals with dysphagia struggle with certain foods or liquids, while others are unable to swallow at all. Additional signs may include coughing or choking during meals, regurgitating food, feeling as though food is stuck in the throat or chest, and continuous drooling.