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Glossary of key terms in PSP
Grasping PSP's intricacies hinges on understanding key definitions and concepts. Familiarity with these principles will help you navigate its complexities.
Randomized
Trial design where participants are randomly assigned to treatment or control groups, ensuring unbiased comparison of outcomes.
Rare disease
A disease is generally defined as rare when it affects fewer than 1 in 2,000 individuals in the general population (in the EU, fewer than 5 in 10,000 people; in the US, fewer than 200,000 people in the US).
Real-world studies (RWS)
Research process that uses health-related data collected outside the strict controls of clinical trials.
Risk factor
Any attribute, characteristic, or exposure that increases an individual's vulnerability to developing a disorder. In PSP, environmental, genetic and epigenetic risk factors, alongside age-related changes, are thought to interact and contribute to the disease; however, the exact underlying cause of this tauopathy is unknown.
Références
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EU Clinical Trials Register. Glossary [Internet]. [cited 2025 Nov]. Available from: https://www.clinicaltrialsregister.eu/doc/EU_Clinical_Trials_Register_Glossary.pdf
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Haendel M, Vasilevsky N, Unni D, et al. How many rare diseases are there? Nat Rev Drug Discov. 2020;19(2):77-78. doi:10.1038/d41573-019-00180-y
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Costa V, Custodio MG, Gefen E, Fregni F. The relevance of real-world evidence in research, clinical, and regulatory decision making. Front Public Health. 2025;13:1512429. doi:10.3389/fpubh.2025.1512429
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ScienceDirect Topics. Risk factor [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/risk-factor
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Park HK, Ilango SD, Litvan I. Environmental risk factors for progressive supranuclear palsy. J Mov Disord. 2021;14(2):103-113. doi:10.14802/jmd.20173