Published content in this website is for information purposes and is intended for healthcare professionals only.
Glossary of key terms in PSP
Grasping PSP's intricacies hinges on understanding key definitions and concepts. Familiarity with these principles will help you navigate its complexities.
Biomarker
A measurable (quantifiable) biological indicator (in blood, spinal fluid, or brain imaging) used for diagnosis, prognosis, and as an endpoint in clinical trials.
Blood-brain barrier
A biological barrier created by closely connected cells that regulate the passage of molecules from the blood into the central nervous system. It selectively permits essential substances such as water, oxygen, and certain drugs to enter the brain while restricting others.
Bradykinesia
Slowness of movement, which can also encompass a difficulty initiating movement.
Bradyphrenia
Noticeable slowing of thought processes, evident to the patient or to someone familiar with them.
Bulbar function
Neurological control of muscles involved in speech, swallowing, and chewing.
Referenties
-
Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987
-
Golbe LI, Ohman-Strickland PA. A clinical rating scale for progressive supranuclear palsy. Brain. 2007;130(Pt 6):1552-1565. doi:10.1093/brain/awm032
-
Marotta C, Gonzalez-Ortiz F, Turton M, Zetterberg H, Harrison P, Hovens CM, Sinclair B, O'Brien TJ, Blennow K, Vivash L. Brain-derived tau to measure treatment effect in Alzheimer's disease and frontotemporal dementia. Alzheimers Dement (Amst). 2025;17(2):e70123. doi:10.1002/dad2.70123
-
National Institute of Neurological Disorders and Stroke (NINDS). Glossary of neurological terms [Internet]. [cited 2025 Nov]. Available from: https://www.ninds.nih.gov/health-information/disorders/glossary-neurological-terms
-
ScienceDirect Topics. Bradykinesia [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/bradykinesia