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Glossary of key terms in PSP
Grasping PSP's intricacies hinges on understanding key definitions and concepts. Familiarity with these principles will help you navigate its complexities.
Gait freezing
Sudden and transient inability to initiate walking, often described as the feet being “glued” to the floor.
Gene
A segment of genetic material (or DNA) that determines inherited characteristics and contributes to the organism’s physiological functions.
Genetic loci/ locus
The specific physical location of a gene or other DNA sequence on a chromosome.
Genome-wide association studies
A research method that examines the entire genome (the complete set of DNA of a person) to detect genetic variants linked to a specific trait or disease.
Glial fibrillary acidic protein (GFAP)
A protein expressed almost exclusively in astrocytes, used as a biomarker of astrocyte injury and neuroinflammation.
References
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Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987
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ScienceDirect Topics. Gene [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/gene
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ScienceDirect Topics. Gene locus [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/immunology-and-microbiology/gene-locus
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ScienceDirect Topics. Genome-wide association study [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/genome-wide-association-study
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Chouliaras L, Thomas A, Malpetti M, et al. Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2022;93(6):651-658. doi:10.1136/jnnp-2021-327788