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Glossary of key terms in PSP
Grasping PSP's intricacies hinges on understanding key definitions and concepts. Familiarity with these principles will help you navigate its complexities.
Saccades
Rapid eye movements that repositions the eyes to a new location.
Safety
The overall assessment of a drug’s adverse effects, tolerability, and risk characteristics.
Sample size
The number of subjects involved in a study. A larger sample size provides stronger evidence, as it is associated with greater statistical power.
Serious adverse event (SAE)
Rapid eye movements that repositions the eyes to a new location.
Splicing
A natural process in cells that edits genes by cutting out unnecessary parts and joining the useful sections together to make a complete instruction for building a protein.
Supportive care
Care given to patients that includes symptomatic treatment but also focuses on improving overall quality of life. In PSP, supportive care can involve physical, occupational and speech therapy and nutritional and psychological support to help patients manage the disease and maintain their independence for as long as possible.
Supranuclear gaze palsy
Impaired voluntary eye movements, especially vertical gaze, more than in the horizontal plane, affecting both up- and downgaze.
Symptomatic treatment
Interventions aimed at alleviating symptoms of a disease rather than addressing the underlying cause.
References
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EU Clinical Trials Register. Glossary [Internet]. [cited 2025 Nov]. Available from: https://www.clinicaltrialsregister.eu/doc/EU_Clinical_Trials_Register_Glossary.pdf
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Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987
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Rowe JB, Holland N, Rittman T. Progressive supranuclear palsy: diagnosis and management. Pract Neurol. 2021;21(5):376-383. doi:10.1136/practneurol-2020-002794
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ScienceDirect Topics. Saccades and fixation [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/engineering/saccades-and-fixation
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ScienceDirect Topics. Sample size [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/sample-size
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National Center for Biotechnology Information (NCBI). MedGen: Serious adverse event [Internet]. [cited 2025 Nov]. Available from: https://www.ncbi.nlm.nih.gov/medgen/276798
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ScienceDirect Topics. DNA splicing [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/dna-splicing
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ScienceDirect Topics. Symptom management [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/symptom-management