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Glossary of key terms in PSP
Grasping PSP's intricacies hinges on understanding key definitions and concepts. Familiarity with these principles will help you navigate its complexities.
Macro square wave jerks
Involuntary, large-amplitude, horizontal eye movements that temporarily move the eyes away from and then back to a fixation point.
Mechanism of action (MoA)
The specific physiological process through which a drug produces its therapeutic effect in the body.
Mentation
Refers to cognitive and mental functioning, such as thinking, memory, attention and judgement.
Microtubules (MTs)
Cylindrical protein filaments forming part of the cell’s cytoskeleton, essential for maintaining cell shape, intracellular transport, and cell division.
Misdiagnosis
An incorrect identification of a disease, often leading to inappropriate treatment or delays in receiving appropriate treatment.
Monoclonal antibodies (mAb)
Laboratory-produced antibodies engineered to recognize and bind specific antigens.
Mortality
In medicine, the term is used as the number of deaths in a population during a specific period of time.
Movement disorders (MD)
Group of neurological conditions primarily affecting the control of voluntary and involuntary movements, resulting in symptoms such as stiffness, slowness or tremors.
Multidisciplinary
An integrated approach to care provided by a team of specialists. In the case of PSP, the multidisciplinary team may include, but are not limited to: neurologist, nurses, physiotherapist, speech therapist, psychologist, dietician, social worker, etc.
Myoclonus
Brief, involuntary muscle contractions.
Powiązania
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Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987
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Golbe LI, Ohman-Strickland PA. A clinical rating scale for progressive supranuclear palsy. Brain. 2007;130(Pt 6):1552-1565. doi:10.1093/brain/awm032
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Kapitein LC, Hoogenraad CC. Building the neuronal microtubule cytoskeleton. Neuron. 2015;87(3):492-506. doi:10.1016/j.neuron.2015.05.046
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Cirinciani M, Da Pozzo E, Trincavelli ML, et al. Drug mechanism: a bioinformatic update. Biochem Pharmacol. 2024;228:116078. doi:10.1016/j.bcp.2024.116078
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ScienceDirect Topics. Misdiagnosis [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/psychology/misdiagnosis
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ScienceDirect Topics. Monoclonal antibody [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/monoclonal-antibody
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ScienceDirect Topics. Mortality [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/immunology-and-microbiology/mortality
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ScienceDirect Topics. Movement disorder [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/movement-disorder
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Rowe JB, Holland N, Rittman T. Progressive supranuclear palsy: diagnosis and management. Pract Neurol. 2021;21(5):376-383. doi:10.1136/practneurol-2020-002794
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ScienceDirect Topics. Myoclonus [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/myoclonus