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Glossary of key terms in PSP
Grasping PSP's intricacies hinges on understanding key definitions and concepts. Familiarity with these principles will help you navigate its complexities.
Neurodegenerative disorder (NDD)
Condition characterized by progressive loss or damage of neurons.
Neurofibrillary tangles (NFT)
Clumps of abnormal tau inside neurons that disrupt their function and lead to cell death.
Neurofilaments (NfL)
Structural proteins of neurons; their breakdown products in blood or CSF reflect non-specific axonal damage and neurodegeneration.
Neuroinflammation
Chronic inflammatory response of the central nervous system to damage, often contributing to neurodegeneration and disease progression.
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Chouliaras L, Thomas A, Malpetti M, et al. Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2022;93(6):651-658. doi:10.1136/jnnp-2021-327788
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ScienceDirect Topics. Neurodegenerative disorder [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/neuroscience/neurodegenerative-disorder
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Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. J Clin Invest. 2023;133(12):e168553. doi:10.1172/JCI168553
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ScienceDirect Topics. Neuroinflammation [Internet]. [cited 2025 Nov]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/neuroinflammation